Neurodevelopmental Disorders

Front Cover
Helen Tager-Flusberg
MIT Press, 1999 - Medical - 614 pages
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The contributions provide in-depth analyses of a broad range of neurodevelopmental disorders, including those resulting from whole chromosome defects (Down and Turner syndromes), those related to defects in a single gene (fragile-X syndrome) or a small number of genes (Williams syndrome), and complex genetic disorders (dyslexia, autism).

Until recently, genetic, neuroanatomical, and psychological investigations on neurodevelopmental disorders were carried out independently. Now, tremendous advances across all disciplines have brought us toward a new scientific frontier: the integration of molecular genetics with a developmental cognitive neuroscience. The goal is to understand the basic mechanisms by which genes and environmental processes contribute to the development of specific structures and regions of the brain.

This handbook-style volume explores these advances from the perspective of developmental disorders in children. Research on children with known genetic disorders offers insights into the genetic mechanisms that underlie neural development and organization, as expressed in variations in cognitive profiles. The contributions provide in-depth analyses of a broad range of neurodevelopmental disorders, including those resulting from whole chromosome defects (Down and Turner syndromes), those related to defects in a single gene (fragile-X syndrome) or a small number of genes (Williams syndrome), and complex genetic disorders (dyslexia, autism). Contributors from the fields of teratology and brain injury provide additional perspectives.

Contributors
Jane Adams, Marcia A. Barnes, Simon Baron-Cohen, Elizabeth Bates, Margaret L. Bauman, Ursula Bellugi, Jacquelyn Bertrand, Lori Buchanan, Merlin G. Butler, Dawn Delaney, Maureen Dennis, Kim N. Dietrich, Elizabeth M. Dykens, Jack M. Fletcher, Susan E. Folstein, Barbara R. Foorman, Albert Galaburda, Randi J. Hagerman, John Harrison, C. Ross Hetherington, Greg Hickok, Terry Jernigan, Beth Joseph, William E. MacLean, Jr., Michele M.M. Mazzocco, William M. McMahon, Carolyn B. Mervis, Debra Mills, Colleen A. Morris, Lynn Nadel, Bruce F. Pennington, Allan L. Reiss, Mabel L. Rice, Byron F. Robinson, Judith L. Ross, Joanne Rovet, Susan L. Santangelo, Bennett A. Shaywitz, Sally E. Shaywitz, Marian Sigman, Helen Tager-Flusberg, Travis Thompson, J. Bruce Tomblin, Doris Trauner, Stefano Vicari, Xuyang Zhang, Andrew Zinn

 

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Contents

An Introduction to Research on Neurodevelopmental Disorders
3
Randi Jenssen Hagerman
27
Syndrome
43
Findings from an Integrated Program
65
Linking Cognition Brain Structure and Brain Function
111
Dykens
137
Cognition Behavior Neurochemistry and Genetics in Prader
155
Developmental Deficits in Children with Down Syndrome
179
Specific Grammatical Limitations in Children with Specific
331
Language Patterns and Etiology in Children with Specific
361
Clinical Features and Neurobiological Observations
383
The Extreme MaleBrain Theory of Autism
401
A Genetic Perspective
431
Perspectives from
451
Environmental Toxicants and Child Development
469
A Challenge for Developmental Cognitive
491

Down Syndrome in Cognitive Neuroscience Perspective
197
A Cognitive Neuroscience Approach
223
Potential Hormonal and Genetic Influences
251
43
265
111
305
Dyslexia as a Neurodevelopmental Disorder
307
Congenital Hydrocephalus as a Model of Neurodevelopmental
505
Perspectives from
533
Advances in the Cognitive Neuroscience of Neurodevelopmental
583
Contributors
601
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